hydroxamic acids การใช้

• Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.
• GM6001 is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors.
• Hadacidin is the simplest known naturally occurring hydroxamic acid.
• The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc.
• The hydroxylamino group of hydroxamic acids of fungal origin has a nitrogen with oxidation state of-1.
• Bilger's studies of nitrogenous compounds began with her thesis work, which concerned hydroxylamines and hydroxamic acids.
• Of the benzene derivatives that do not undergo the Baudisch reaction, aromatic aldehydes tend to form hydroxamic acid or oximes.
• Dissolved Cm 3 + ions bind with many organic compounds, such as hydroxamic acid, urea, fluorescein and adenosine triphosphate.
• Dr . Paul R . Sleath, a chemist with Immunex, developed the hydroxamic acid compound that inhibits the processing of the factor.
• This compound, isolated and characterized by Kaczka et al . ( 1962 ), seemed well suited for a study of the route of hydroxamic acid biosynthesis.
• The toxicity of aspergillic acid is controlled by the hydroxamic acid functionality, and there is little effect on toxicity observed between the differences in the 3 and 6 position side chain substituents.
• DIMBOA is a member of a group of hydroxamic acids ( also known as benzoxazinoids ) that serve as a natural defense against a wide range of pests, including insects, pathogenic fungi and bacteria.
• The major toxins involved in " A . muscaria " poisoning are muscimol ( 3-hydroxy-5-aminomethyl-1-isoxazole, an unsaturated cyclic hydroxamic acid ) and the related amino acid ibotenic acid.
• The fungus does not require a specific soil but seems to prefer acidic and nutrient-deficient soil . " Suillus luteus " produces hydroxamic acid-based siderophores, which are compounds that can carbon dioxide levels in the atmosphere.
• "Second-generation " HDIs include the hydroxamic acids vorinostat ( SAHA ), belinostat ( PXD101 ), LAQ824, and panobinostat ( LBH589 ); and the benzamides : entinostat ( MS-275 ), CI994, and mocetinostat ( MGCD0103 ).
• "' Pracinostat "'( "'SB939 "') is an orally bioavailable, small-molecule histone deacetylase ( HDAC ) inhibitor based on hydroxamic acid with potential anti-tumor activity characterized by favorable physicochemical, pharmaceutical, and pharmacokinetic properties.
• The mechanism below begins with an O-acylated hydroxamic acid derivative that is treated with base to form an isocyanate that generates an amine and CO 2 gas in the presence of H 2 O . The hydroxamic acid acid derivative is first converted to its conjugate base by abstraction of a hydrogen by a base.
• The mechanism below begins with an O-acylated hydroxamic acid derivative that is treated with base to form an isocyanate that generates an amine and CO 2 gas in the presence of H 2 O . The hydroxamic acid acid derivative is first converted to its conjugate base by abstraction of a hydrogen by a base.
• Compounds which increased " SMN2 " activity " in vitro " but did not make it to the clinical stage include growth hormone, various histone deacetylase inhibitors, benzamide M344, hydroxamic acids ( CBHA, SBHA, entinostat, panobinostat, trichostatin A, vorinostat ), prolactin as well as natural polyphenol compounds like resveratrol and curcumin.
• In addition, the cytosolic " N ", " O "-aryl hydroxamic acid acyltransferase enzyme catalyzes the transfer of the acetyl group from the N atom of the N-OH-2-AAF to the O atom of the N-OH group to produce N-acetoxy-2-aminofluorene ( N-OH-2-AF ).